Derivation and Validation of a Clinical and Endothelial Biomarker Risk Model to Predict Persistent Pediatric Sepsis-Associated Acute Respiratory Dysfunction

Derivation and Validation of a Clinical and Endothelial Biomarker Risk Model to Predict Persistent Pediatric Sepsis-Associated Acute Respiratory Dysfunction

Background: Sepsis-associated ARDS results in high morbidity and mortality in children. However, heterogeneity among patients makes identifying those at risk of persistent acute respiratory dysfunction challenging. Endothelial dysfunction is a key feature of ARDS pathophysiologic characteristics, co...

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Main Authors: James G. Williams, MD, Jane E. Whitney, MD, Scott L. Weiss, MD, Brian M. Varisco, MD, Nadir Yehya, MD, Mihir R. Atreya, MD, MPH
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:CHEST Critical Care
Subjects:
biomarkers
endothelial dysfunction
precision medicine
sepsis-associated respiratory dysfunction
septic shock
Online Access:http://www.sciencedirect.com/science/article/pii/S2949788424000741
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