MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma

MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma

Abstract The oncoprotein MYCN drives malignancy in various cancer types, including neuroblastoma (NB). However, our understanding of the mechanisms underlying its transcriptional activity and oncogenic function, as well as effective strategies to target it, remains limited. We discovered that MYCN i...

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Main Authors: Zhihui Liu, Jason J. Hong, Xiyuan Zhang, Carly M. Sayers, Wendy Fang, Man Xu, Sydney Loria, Sakereh Maskal, Haiyan Lei, Haitao Wu, Rolf Swenson, Jordan L. Meier, Jack F. Shern, Carol J. Thiele
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-025-00557-2
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https://doi.org/10.1038/s41389-025-00557-2

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