2-Dodecyl-6-methoxycyclohexa-2,5-dien-1,4-dione alleviates liver fibrosis and improves intestinal flora and bile acid metabolism

2-Dodecyl-6-methoxycyclohexa-2,5-dien-1,4-dione alleviates liver fibrosis and improves intestinal flora and bile acid metabolism

BackgroundThe bioactive compound 2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD), derived from the horn root of star fruit, exhibits therapeutic promise through its modulation of the TGF-β1 pathway and regulation of bile acids.MethodsIn this study, a liver fibrosis model was established in K...

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Bibliographic Details
Main Authors: Yongfei He, Thi Thai Hoa Pham, Junming Xu, Shengjie Hong, Jicai Wang, Hang Zhai, Qiang Tao, Ruixi Li, Guangquan Zhang, Xianjie Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
2-dodecyl-6-methoxycyclohexa-2,5-dien-1,4-dione
liver fibrosis
bile acid metabolism
intestinal flora
transcriptomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1581138/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1581138/full

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