Impact of Capsaicinoid Supplementation in Health and Performance of Broiler Chickens Subjected to Lipopolysaccharide Challenge
This study investigated the effects of dietary capsaicinoid (CAP) supplementation on broiler chickens subjected to an inflammatory challenge induced by lipopolysaccharide (LPS). A total of 144 Cobb500™ male broilers (Rivelli Alimentos SA, Matheus Leme, Brazil), raised from 1 to 21 days, were randoml...
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MDPI AG
2025-07-01
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| author | Rayanne A. Nunes Kelly M. M. Dias Marcio S. Duarte Claudson O. Brito Ricardo V. Nunes Tiago G. Petrolli Samuel O. Borges Larissa P. Castro Beatriz G. Vale Arele A. Calderano |
| author_facet | Rayanne A. Nunes Kelly M. M. Dias Marcio S. Duarte Claudson O. Brito Ricardo V. Nunes Tiago G. Petrolli Samuel O. Borges Larissa P. Castro Beatriz G. Vale Arele A. Calderano |
| author_sort | Rayanne A. Nunes |
| collection | DOAJ |
| description | This study investigated the effects of dietary capsaicinoid (CAP) supplementation on broiler chickens subjected to an inflammatory challenge induced by lipopolysaccharide (LPS). A total of 144 Cobb500™ male broilers (Rivelli Alimentos SA, Matheus Leme, Brazil), raised from 1 to 21 days, were randomly assigned to three treatments, with eight replicates of six birds. Treatments were a control diet (CON), a control diet with LPS administration (CON+LPS), and a control diet supplemented with 1 mg CAP/kg feed and LPS (CAP+LPS). LPS was administered intraperitoneally on days 14, 16, 18, and 20. Performance, intestinal morphometry, serum metabolites, and jejunal gene expression related to oxidative and inflammatory responses were evaluated. Slaughter was at 20 days. Data were subjected to ANOVA and means compared by Tukey’s test at 0.05 significance. CON broilers exhibited the highest feed intake and a better feed conversion ratio (<i>p</i> < 0.05) compared to CON+LPS. CAP+LPS broilers showed higher body weight gain than CON+LPS but lower than CON broilers (<i>p</i> < 0.001). CON+LPS broilers had the highest crypt depth (<i>p</i> = 0.002). Higher mRNA expression of superoxide dismutase and catalase (<i>p</i> > 0.05) was observed in CON broilers. In conclusion, supplementation with a 1 mg CAP/kg diet improves the growth performance and intestinal morphometry of LPS-challenged broiler chickens. |
| format | Article |
| id | doaj-art-a440331d919443b3bb72fa628c0c53df |
| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj-art-a440331d919443b3bb72fa628c0c53df2025-08-20T03:35:57ZengMDPI AGAnimals2076-26152025-07-011515220310.3390/ani15152203Impact of Capsaicinoid Supplementation in Health and Performance of Broiler Chickens Subjected to Lipopolysaccharide ChallengeRayanne A. Nunes0Kelly M. M. Dias1Marcio S. Duarte2Claudson O. Brito3Ricardo V. Nunes4Tiago G. Petrolli5Samuel O. Borges6Larissa P. Castro7Beatriz G. Vale8Arele A. Calderano9Department of Animal Science, Federal University of Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Animal Science, Federal University of Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Animal Science, Federal University of Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Animal Science, Federal University of Sergipe, São Cristóvão 49100-000, SE, BrazilDepartment of Animal Science, State University of Western Paraná, Marechal Cândido Rondon 85960-128, PR, BrazilDepartment of Animal Science, University of the West of Santa Catarina, Xanxerê 89820-000, SC, BrazilDepartment of Animal Science, Federal University of Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Animal Science, Federal University of Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Animal Science, Federal University of Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Animal Science, Federal University of Viçosa, Viçosa 36570-900, MG, BrazilThis study investigated the effects of dietary capsaicinoid (CAP) supplementation on broiler chickens subjected to an inflammatory challenge induced by lipopolysaccharide (LPS). A total of 144 Cobb500™ male broilers (Rivelli Alimentos SA, Matheus Leme, Brazil), raised from 1 to 21 days, were randomly assigned to three treatments, with eight replicates of six birds. Treatments were a control diet (CON), a control diet with LPS administration (CON+LPS), and a control diet supplemented with 1 mg CAP/kg feed and LPS (CAP+LPS). LPS was administered intraperitoneally on days 14, 16, 18, and 20. Performance, intestinal morphometry, serum metabolites, and jejunal gene expression related to oxidative and inflammatory responses were evaluated. Slaughter was at 20 days. Data were subjected to ANOVA and means compared by Tukey’s test at 0.05 significance. CON broilers exhibited the highest feed intake and a better feed conversion ratio (<i>p</i> < 0.05) compared to CON+LPS. CAP+LPS broilers showed higher body weight gain than CON+LPS but lower than CON broilers (<i>p</i> < 0.001). CON+LPS broilers had the highest crypt depth (<i>p</i> = 0.002). Higher mRNA expression of superoxide dismutase and catalase (<i>p</i> > 0.05) was observed in CON broilers. In conclusion, supplementation with a 1 mg CAP/kg diet improves the growth performance and intestinal morphometry of LPS-challenged broiler chickens.https://www.mdpi.com/2076-2615/15/15/2203feed additiveinflammationantioxidantpoultry |
| spellingShingle | Rayanne A. Nunes Kelly M. M. Dias Marcio S. Duarte Claudson O. Brito Ricardo V. Nunes Tiago G. Petrolli Samuel O. Borges Larissa P. Castro Beatriz G. Vale Arele A. Calderano Impact of Capsaicinoid Supplementation in Health and Performance of Broiler Chickens Subjected to Lipopolysaccharide Challenge Animals feed additive inflammation antioxidant poultry |
| title | Impact of Capsaicinoid Supplementation in Health and Performance of Broiler Chickens Subjected to Lipopolysaccharide Challenge |
| title_full | Impact of Capsaicinoid Supplementation in Health and Performance of Broiler Chickens Subjected to Lipopolysaccharide Challenge |
| title_fullStr | Impact of Capsaicinoid Supplementation in Health and Performance of Broiler Chickens Subjected to Lipopolysaccharide Challenge |
| title_full_unstemmed | Impact of Capsaicinoid Supplementation in Health and Performance of Broiler Chickens Subjected to Lipopolysaccharide Challenge |
| title_short | Impact of Capsaicinoid Supplementation in Health and Performance of Broiler Chickens Subjected to Lipopolysaccharide Challenge |
| title_sort | impact of capsaicinoid supplementation in health and performance of broiler chickens subjected to lipopolysaccharide challenge |
| topic | feed additive inflammation antioxidant poultry |
| url | https://www.mdpi.com/2076-2615/15/15/2203 |
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