Engineering of CD63 Enables Selective Extracellular Vesicle Cargo Loading and Enhanced Payload Delivery

Engineering of CD63 Enables Selective Extracellular Vesicle Cargo Loading and Enhanced Payload Delivery

ABSTRACT Extracellular vesicles (EVs) are mediators of intercellular communication through the transfer of nucleic acids, lipids and proteins between cells. This property makes bioengineered EVs promising therapeutic vectors. However, it remains challenging to isolate EVs with a therapeutic payload...

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Main Authors: Wataru Obuchi, Ayrton Zargani‐Piccardi, Kevin Leandro, David Rufino‐Ramos, Emilio Di Ianni, Dawn Madison Frederick, Katia Maalouf, Lisa Nieland, Tianhe Xiao, Pierre Repiton, Christine A. Vaine, Benjamin P. Kleinstiver, D. Cristopher Bragg, Hakho Lee, Miles A. Miller, Xandra O. Breakefield, Koen Breyne
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Journal of Extracellular Vesicles
Subjects:
Cre recombinase
CRISPR
gene therapy
enveloped delivery vehicles
extracellular vesicles
virus‐like particles
Online Access:https://doi.org/10.1002/jev2.70094
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https://doi.org/10.1002/jev2.70094

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