Sulforaphane induces cell morphology change and cell apoptosis by activating endoplasmic reticulum stress in glioblastoma

Sulforaphane induces cell morphology change and cell apoptosis by activating endoplasmic reticulum stress in glioblastoma

Abstract Background Sulforaphane (SFN), a naturally occurring isothiocyanate derived from cruciferous vegetables, has shown promise as a multitargeted therapeutic agent in glioblastoma (GBM). This study aimed to elucidate the role and underlying molecular mechanisms of SFN in regulating GBM progress...

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Bibliographic Details
Main Authors: Nan Li, Yan Jiang, Ajun Wang, Tongchao Jiang, Huimin Dai, Chengyu Xia, Tongcui Jiang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
Sulforaphane
Endoplasmic reticulum stress
Unfolded protein response
Cleaved Caspase-3
Glioblastoma
In vivo model
Online Access:https://doi.org/10.1186/s12885-025-14378-4
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https://doi.org/10.1186/s12885-025-14378-4

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