A CRISPR‐nonhomologous end‐joining‐based strategy for rapid and efficient gene disruption in Mycobacterium abscessus

A CRISPR‐nonhomologous end‐joining‐based strategy for rapid and efficient gene disruption in Mycobacterium abscessus

Abstract Mycobacterium abscessus, a fast‐growing, non‐tuberculous mycobacterium resistant to most antimicrobial drugs, causes a wide range of serious infections in humans, posing a significant public health challenge. The development of effective genetic manipulation tools for M. abscessus is still...

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Main Authors: Sanshan Zeng, Yanan Ju, Md Shah Alam, Ziwen Lu, H. M. Adnan Hameed, Lijie Li, Xirong Tian, Cuiting Fang, Xiange Fang, Jie Ding, Xinyue Wang, Jinxing Hu, Shuai Wang, Tianyu Zhang
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:mLife
Subjects:
CRISPR‐Cas12a
DSB repair
Mycobacterium abscessus
NHEJ
NrgA
Online Access:https://doi.org/10.1002/mlf2.70007
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https://doi.org/10.1002/mlf2.70007

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