Oncostatin M enhances the lengthening of sensory nerves and skin hypersensitivity

Oncostatin M enhances the lengthening of sensory nerves and skin hypersensitivity

BackgroundOncostatin M (OSM) is a cytokine that mediates inflammatory processes and is overexpressed in skin lesions of atopic dermatitis (AD). By amplifying neural responses to chemicals such as histamine, OSM increases sensitivity to pruritus. However, the morphological effects of OSM on periphera...

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Main Authors: Chie Ishikawa, Ryo Saito, Masataka Suehiro, Kaori Ishii, Yuhki Yanase, Tomoko Kawaguchi, Kazue Uchida, Nozomi Yanagida, Tomofumi Numata, Wataru Sasaki, Rina Kamigaki, Sachio Takeno, Akio Tanaka
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
atopic dermatitis
nerve elongation
oncostatin M
pruritus
sensory nerve
itch
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571120/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571120/full

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