A Simplified Model of Adenine-Induced Chronic Kidney Disease Using SKH1 Mice

A Simplified Model of Adenine-Induced Chronic Kidney Disease Using SKH1 Mice

Commonly used adenine-induced chronic kidney disease (CKD) murine models often employ C57BL/6 mice; however, this strain has inherent limitations due to its natural resistance to developing key pathological features of CKD, such as tubulointerstitial fibrosis and inflammation. There have been attemp...

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Bibliographic Details
Main Authors: Benjamin W. French, Joshua D. Breidenbach, Shereen G. Yassine, Bella Z. Khatib-Shahidi, Sara Kazmi, Caitlin M. Murphy, Humza S. Bashir, Evan M. Benson, Bivek Timalsina, Upasana Shrestha, Dhilhani Faleel, Satkeerth Boyapalli, Prabhatchandra Dube, Apurva Lad, Irum Syed, Deepak Malhotra, Amira Gohara, David J. Kennedy, Steven T. Haller
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
chronic kidney disease (CKD)
adenine diet model
SKH1 elite mice
renal pathology
dermatological comorbidities
Online Access:https://www.mdpi.com/2073-4409/13/24/2117
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