Phytoactive-Loaded Lipid Nanocarriers for Simvastatin Delivery: A Drug Repositioning Strategy Against Lung Cancer

Phytoactive-Loaded Lipid Nanocarriers for Simvastatin Delivery: A Drug Repositioning Strategy Against Lung Cancer

<b>Background/Objectives:</b> Drug repurposing explores new applications for approved medications, such as simvastatin (SV), a lipid-lowering drug that has shown anticancer potential but is limited by solubility and side effects. This study aims to enhance SV delivery and efficacy agains...

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Main Authors: Rocío Gambaro, Cecilia Y. Chain, Sebastian Scioli-Montoto, Ailin Moreno, Cristián Huck-Iriart, María Esperanza Ruiz, José S. Cisneros, Diego G. Lamas, Julia Tau, Stephan Gehring, Germán A. Islan, Boris Rodenak-Kladniew
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceutics
Subjects:
plant-derived monoterpenes
simvastatin
bioactive lipid nanoparticles
synergism
drug repositioning
lung cancer
Online Access:https://www.mdpi.com/1999-4923/17/2/255
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