An integrated machine learning model of transcriptomic genes in multi-center chronic obstructive pulmonary disease reveals the causal role of TIMP4 in airway epithelial cell

An integrated machine learning model of transcriptomic genes in multi-center chronic obstructive pulmonary disease reveals the causal role of TIMP4 in airway epithelial cell

Abstract Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome, resulting in inconsistent findings across studies. Identifying a core set of genes consistently involved in COPD pathogenesis, independent of patient variability, is essential. Methods We integrated lung ti...

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Main Authors: Erkang Yi, Haiqing Li, Yu Liu, Qingyang Li, Chengshu Xie, Ruining Sun, Fan Wu, Zhishan Deng, Kunning Zhou, Hairong Wang, Xinru Ran, Yumin Zhou, Pixin Ran
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Respiratory Research
Subjects:
Chronic obstructive pulmonary disease
Machine learning
Mendelian randomization
Matrix metallopeptidase 4
Online Access:https://doi.org/10.1186/s12931-025-03238-1
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https://doi.org/10.1186/s12931-025-03238-1

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