Defects in mitophagy promote redox‐driven metabolic syndrome in the absence of TP53INP1

Defects in mitophagy promote redox‐driven metabolic syndrome in the absence of TP53INP1

Abstract The metabolic syndrome covers metabolic abnormalities including obesity and type 2 diabetes (T2D). T2D is characterized by insulin resistance resulting from both environmental and genetic factors. A genome‐wide association study (GWAS) published in 2010 identified TP53INP1 as a new T2D susc...

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Main Authors: Marion Seillier, Laurent Pouyet, Prudence N'Guessan, Marie Nollet, Florence Capo, Fabienne Guillaumond, Laure Peyta, Jean‐François Dumas, Annie Varrault, Gyslaine Bertrand, Stéphanie Bonnafous, Albert Tran, Gargi Meur, Piero Marchetti, Magalie A Ravier, Stéphane Dalle, Philippe Gual, Dany Muller, Guy A Rutter, Stéphane Servais, Juan L Iovanna, Alice Carrier
Format: Article
Language:English
Published: Springer Nature 2015-03-01
Series:EMBO Molecular Medicine
Subjects:
autophagy
diabetes
mitochondria
obesity
oxidative stress
Online Access:https://doi.org/10.15252/emmm.201404318
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https://doi.org/10.15252/emmm.201404318

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