Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

Abstract Beyond inherently killing cancer cells by directly inducing double‐strand DNA breaks, local radiotherapy (RT) can exert immune‐priming effects and reprogram the tumor microenvironment (TME) from immune‐cold tumors into inflamed, or “hot” tumors. Nevertheless, this immunogenic antitumor resp...

Full description

Saved in:
Bibliographic Details
Main Authors: Lijuan Lyu, Ming Yi, Ji Chen, Jing Zhang, Xiaobin Ma, Xiaojun Zhang, Liang Zeng, Yan Xue, Haimei Wen, Yujiao Deng, Pengfei Zhou, Kongming Wu, Huafeng Kang, Zhijun Dai
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
abscopal effects
bispecific antibody
radiotherapy
tumor microenvironment
TGF‐β
VEGF
Online Access:https://doi.org/10.1002/advs.202501819
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/advs.202501819

Similar Items