Elucidating SARS-CoV-2 neurotropism: a comprehensive Mendelian randomization study on cerebrospinal fluid biomarkers and their relevance to COVID-19 neurological manifestations

Elucidating SARS-CoV-2 neurotropism: a comprehensive Mendelian randomization study on cerebrospinal fluid biomarkers and their relevance to COVID-19 neurological manifestations

Abstract A mendelian randomization (MR) analysis was conducted to investigate whether SARS-CoV-2 invaded the human nervous system. This was confirmed by an increase in biomarkers found in the cerebrospinal fluid (CSF) and plasma of COVID-19 patients. To confirm the neuroinvasive properties of SARS-C...

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Bibliographic Details
Main Authors: Ziyan Wu, Honglin Xu, Siyuan Fan, Futai Feng, Zhan Li, Linlin Cheng, Haolong Li, Yongmei Liu, Haoting Zhan, Xinxin Feng, Siyu Wang, Shulan Zhang, Yongzhe Li
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Virology Journal
Subjects:
Mendelian randomization
COVID-19
Neurological complications
CSF
Neuroinflammation.
Online Access:https://doi.org/10.1186/s12985-025-02754-2
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https://doi.org/10.1186/s12985-025-02754-2

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