Hereditary breast cancer: genetic and clinical hetergeneity, genetic testing, prophylactic surgery

Hereditary breast cancer: genetic and clinical hetergeneity, genetic testing, prophylactic surgery

5–10 % of breast cancer cases are hereditary, 30 % of them are caused by BRCA1 and BRCA2 mutations (breast / ovarian cancer syndrome). Average cumulative risks of breast and ovarian cancer in BRCA1 mutation carriers run up to 87 % and 44 %, correspondingly. The risk for contralateral breast cancer i...

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Bibliographic Details
Main Authors: L. N. Lyubchenko, Ye. I. Bateneva, I. K. Vorotnikov, S. M. Portnoy, O. V. Krokhina, V. A. Sobolevskiy, L. G. Zhukova, V. A. Khaylenko, S. A. Tyulyandin
Format: Article
Language:Russian
Published: ABV-press 2015-06-01
Series:Успехи молекулярной онкологии
Subjects:
hereditary breast cancer
hereditary ovarian cancer
brca1
brca2
mutation
single nucleotide polymorphism
genetic counselling
genetic testing
prophylactic mastectomy
prophylactic oophorectomy
Online Access:https://umo.abvpress.ru/jour/article/view/20
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