N-Cadherin based adhesion and Rac1 activity regulate tension polarization in the actin cortex

N-Cadherin based adhesion and Rac1 activity regulate tension polarization in the actin cortex

Abstract Tension-adhesion interplay is a crucial mechanism in multicellular organisms that determines the tension differential among internal and external interfaces, which in turn, mediates tissue surface tension and cell sorting, morphogenesis and remodeling, and cancer progression. Cadherins are...

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Bibliographic Details
Main Authors: Seyedsajad Moazzeni, Kelly Kyker-Snowman, Rick I. Cohen, Huan Wang, Ran Li, David I. Shreiber, Jeffrey D. Zahn, Zheng Shi, Hao Lin
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Cadherin-based cell adhesion
Cortical tension
Tension polarization
Mechanotransduction
Multicellular organization
Mechanobiology
Online Access:https://doi.org/10.1038/s41598-025-88537-9
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https://doi.org/10.1038/s41598-025-88537-9

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