Steviol rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments

Steviol rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments

Abstract Sucrose provides both sweetness and energy by binding to both Venus flytrap domains (VFD) of the heterodimeric sweet taste receptor (T1R2/T1R3). In contrast, non-caloric sweeteners such as sucralose and aspartame only bind to one specific domain (VFD2) of T1R2, resulting in high-intensity s...

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Bibliographic Details
Main Authors: Shuang Hao, Brian Guthrie, Soo-Kyung Kim, Sergej Balanda, Jan Kubicek, Babar Murtaza, Naim A. Khan, Pouyan Khakbaz, Judith Su, William A. Goddard
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-024-01324-x
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https://doi.org/10.1038/s42004-024-01324-x

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