Effects of neutrophil granule proteins on sepsis-associated lymphopenia and their relationship with CD4+ T-cell pyroptosis

Effects of neutrophil granule proteins on sepsis-associated lymphopenia and their relationship with CD4+ T-cell pyroptosis

BackgroundNeutrophil acts as a double-edged sword in the immune system. We hypothesized that an elevated neutrophil granule protein level is associated with sepsis-associated lymphopenia (SAL).MethodsWe enrolled 61 patients with sepsis admitted to the Department of Critical Care Medicine of Peking U...

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Bibliographic Details
Main Authors: Jia-yu Mao, Ya-wen Xie, Xian-li Lei, Jia-hui Zhang, Wei Cheng, Na Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
sepsis
sepsis-associated lymphopenia
neutrophil granule proteins
CD4 lymphocytes
pyroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1507800/full
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