Deferoxamine prevents dexamethasone-induced muscle atrophy by reducing MuRF1 and atrogin-1

Deferoxamine prevents dexamethasone-induced muscle atrophy by reducing MuRF1 and atrogin-1

IntroductionMuscle atrophy, commonly triggered by glucocorticoids such as dexamethasone (DEX), involves increased protein degradation via the ubiquitin–proteasome system. Recent findings suggest that iron imbalance can also induce muscle atrophy. However, there have been no reports indicating that D...

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Main Authors: Jae-Yeop Jeong, Youngho Son, Youngha Kim, Nami Lee, Yujin Kim, Yu Jung Heo, Sung-E. Choi, Jaemyung Choi, Seung Jin Han, Jayoung Jeon, Hae Jin Kim, Kwan-Woo Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
muscle atrophy
dexamethasone
deferoxamine
MuRF1
atrogin-1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1582216/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1582216/full

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