Epitope mapping using immunopeptidomics reveals novel immunodominant CD8 T cell epitopes of the AAV9 capsid

Epitope mapping using immunopeptidomics reveals novel immunodominant CD8 T cell epitopes of the AAV9 capsid

IntroductionAdeno-associated virus (AAV)-mediated gene therapy is a promising approach to treat genetic disorders, offering advantages such as high transduction efficiency, diverse tissue tropism, and an acceptable safety profile. However, the immunogenicity of AAV vectors, particularly the activati...

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Bibliographic Details
Main Authors: Akhila Balasubramanian, Marek Prachar, Birgit Klaproth, Victoria Copeland, Sune Justesen, Yi Wen, Robert W. Siegel, Laurent P. Malherbe
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
AAV9
immunopeptidomics
HLA class I
CD8 T cells
capsid epitopes
immune monitoring
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1641289/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1641289/full

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