Marek’s disease virus protein kinase US3 inhibits DNA-sensing antiviral innate immunity via abrogating activation of NF-κB

Marek’s disease virus protein kinase US3 inhibits DNA-sensing antiviral innate immunity via abrogating activation of NF-κB

ABSTRACT Marek’s disease virus (MDV) is an avian alphaherpesvirus associated with Marek’s disease, an immunosuppressive and lymphoproliferative disease in chickens. The DNA sensing pathway mediates innate immune defense against infection by many DNA-containing pathogens, while viruses have evolved m...

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Bibliographic Details
Main Authors: Kai Li, Rui Liu, Yongzhen Liu, Li Gao, Changjun Liu, Yanping Zhang, Xiaole Qi, Hongyu Cui, Suyan Wang, Yuntong Chen, Yulu Duan, Yulong Gao, Xiaomei Wang
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:Microbiology Spectrum
Subjects:
Marek’s disease virus
US3
innate immunity
DNA sensing
NF-κB
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02347-24
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https://journals.asm.org/doi/10.1128/spectrum.02347-24

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