Endogenous OptoRhoGEFs reveal biophysical principles of epithelial tissue furrowing

Abstract During development, epithelia function as malleable sheets that undergo extensive remodeling to shape developing embryos. Optogenetic control of Rho signaling provides an avenue to investigate mechanisms of epithelial morphogenesis, but transgenic optogenetic tools can be limited by variabi...

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Bibliographic Details
Main Authors: Andrew D. Countryman, Caroline A. Doherty, R. Marisol Herrera-Perez, Karen E. Kasza
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62483-6
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