A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses and vaccine efficacy is determined by adjuvant and dosage

A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses and vaccine efficacy is determined by adjuvant and dosage

The H5N1 subtype highly pathogenic avian influenza virus (HPAIV) reveals high variability and threatens poultry production and public health. To prevent the spread of H5N1 HPAIV, we developed an H5N1 virus-like particle (VLP) vaccine based on the insect cell-baculovirus expression system. Single imm...

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Bibliographic Details
Main Authors: Dexin Kong, Yanjuan He, Jiaxin Wang, Lanyan Chi, Xiang Ao, Hejia Ye, Weihong Qiu, Xiutong Zhu, Ming Liao, Huiying Fan
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
H5N1
virus-like particle
adjuvant
vaccine dose
neutralizing antibodies
cross-protection
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2287682
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https://www.tandfonline.com/doi/10.1080/22221751.2023.2287682

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