Efficacy and safety of heart rate control with esmolol on the incidence and duration of organ failure in predicted severe acute pancreatitis: protocol of a multicenter, open-label, randomized controlled trial

Efficacy and safety of heart rate control with esmolol on the incidence and duration of organ failure in predicted severe acute pancreatitis: protocol of a multicenter, open-label, randomized controlled trial

IntroductionOveractivation of the sympathetic nerve system can lead to a sustained increase in heart rate, which may impair blood perfusion and organ function. Previous studies have demonstrated that the use of β-blockers like esmolol can reduce heart rate, thereby improving clinical outcomes in pat...

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Main Authors: Mingfeng Huang, Rong Wei, Lu Ke, Weijian Li, Jian Song, Haibin Ni, Xiaofei Huang, Yun Sun, Lu Fu, Yanhua Li, Dong Zhang, Bin Han, Jing Zhang, Yingying Hu, Chong Zhang, Zhongyan Sheng, Wenwen Feng, Lin Gao, Wenjian Mao, Yuxiu Liu, Bo Ye, Zhihui Tong, Weiqin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Medicine
Subjects:
acute pancreatitis
β-blockers
esmolol
heart rate
organ function
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1642721/full
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