The modulating role of uniaxial straining in the IL-1β and TGF-β mediated inflammatory response of human primary ligamentocytes

The modulating role of uniaxial straining in the IL-1β and TGF-β mediated inflammatory response of human primary ligamentocytes

Biomechanical (over-)stimulation, in addition to inflammatory and fibrotic stimuli, severely impacts the anterior cruciate ligament (ACL) biology, contributing to the overall chronic nature of desmopathy. A major challenge has been the lack of representative two-dimensional (2D) in vitro models mimi...

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Main Authors: Johannes Heidenberger, Raphael Hangel, Eva I. Reihs, Jonathan Strauss, Petra Liskova, Jürgen Alphonsus, Cornelia Brunner, Kevin Döring, Iris Gerner, Florien Jenner, Reinhard Windhager, Stefan Toegel, Mario Rothbauer
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
mechanical loading
ligamentocytes
inflammation
fibrosis
in vitro modelling
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1469238/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2024.1469238/full

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