miR-29a-3p and TGF-β Axis in Fanconi anemia: mechanisms driving metabolic dysfunction and genome stability

miR-29a-3p and TGF-β Axis in Fanconi anemia: mechanisms driving metabolic dysfunction and genome stability

Abstract Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and cancer predisposition. The FA cellular phenotype is marked by a defective DNA double-strand break repair. Alongside this defect, FA cells exhibit mitochondrial dysfunction and redox unbalance. In addition, FA...

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Main Authors: Nadia Bertola, Stefano Regis, Vanessa Cossu, Matilde Balbi, Martina Serra, Fabio Corsolini, Cristina Bottino, Paolo Degan, Carlo Dufour, Filomena Pierri, Enrico Cappelli, Silvia Ravera
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
DNA repair
Fanconi anemia
Inflammation
MiR-29a-3p
Mitochondrial metabolism
Online Access:https://doi.org/10.1007/s00018-025-05775-w
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https://doi.org/10.1007/s00018-025-05775-w

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