Alpha-synuclein pathology enhances peripheral and CNS immune responses to bacterial endotoxins

Alpha-synuclein pathology enhances peripheral and CNS immune responses to bacterial endotoxins

Increasing evidence points to infectious diseases as contributor to the pathogenesis of neurodegeneration in Parkinson's disease (PD), probably driven by a peripheral and CNS inflammatory response together with alpha-synuclein (aSyn) pathology. Pro-inflammatory lipopolysaccharide (LPS) endotoxi...

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Bibliographic Details
Main Authors: Anna-Sophia Hartke, Cara S. Schreiber, Kristina Lau, Ivo Wiesweg, Inken Waltl, Ulrich Kalinke, Franziska Richter, Christopher Käufer
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Neurobiology of Disease
Subjects:
Alpha-Synuclein
Parkinson's disease
Lipopolysaccharide
Neurodegenerative disease
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003759
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