Emerging role of SETD2 in the development and function of immune cells
SET domain-containing 2 (SETD2) is a methyltransferase that catalyzes trimethylation of lysine 36 on H3 (H3K36me3) in mammals, an epigenetic mark associated with actively transcribed regions. SETD2 is implicated in multiple chromatin biological processes, such as alternative splicing, transcriptiona...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-11-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304225001114 |
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| author | Longmin Chen Yuan Zou Yan Dong Tian Hong Qianqian Xu Jing Zhang |
| author_facet | Longmin Chen Yuan Zou Yan Dong Tian Hong Qianqian Xu Jing Zhang |
| author_sort | Longmin Chen |
| collection | DOAJ |
| description | SET domain-containing 2 (SETD2) is a methyltransferase that catalyzes trimethylation of lysine 36 on H3 (H3K36me3) in mammals, an epigenetic mark associated with actively transcribed regions. SETD2 is implicated in multiple chromatin biological processes, such as alternative splicing, transcriptional regulation, DNA damage repair, and maintenance of genomic integrity. Extensive studies have demonstrated that SETD2-inactivating mutations and resultant dysregulation of these functions may result in tumorigenesis. However, the role of SETD2 in the development and function of immune cells receives relatively limited attention. In this review, we seek to summarize current knowledge of the biological function and underlying mechanisms of SETD2 and highlight its important role in immune cell biology. By influencing the biological processes of immune cells, SETD2 participates in the pathogenesis of immune-related diseases, including infection, cancers, autoimmune diseases, and inflammatory diseases. Finally, we discuss challenges and prospects for targeting SETD2 in immune cells to provide guidance for treating those diseases in clinical practice. |
| format | Article |
| id | doaj-art-a2650cbdb75d4d46a8c7649bfec8916d |
| institution | Kabale University |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-a2650cbdb75d4d46a8c7649bfec8916d2025-08-24T05:13:07ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-11-0112610162210.1016/j.gendis.2025.101622Emerging role of SETD2 in the development and function of immune cellsLongmin Chen0Yuan Zou1Yan Dong2Tian Hong3Qianqian Xu4Jing Zhang5Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430100, China; Department of Rheumatology and Immunology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, ChinaDepartment of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, ChinaDepartment of Rheumatology and Immunology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, ChinaDepartment of Gerontology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, ChinaDepartment of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430100, ChinaDepartment of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430100, China; Corresponding author.SET domain-containing 2 (SETD2) is a methyltransferase that catalyzes trimethylation of lysine 36 on H3 (H3K36me3) in mammals, an epigenetic mark associated with actively transcribed regions. SETD2 is implicated in multiple chromatin biological processes, such as alternative splicing, transcriptional regulation, DNA damage repair, and maintenance of genomic integrity. Extensive studies have demonstrated that SETD2-inactivating mutations and resultant dysregulation of these functions may result in tumorigenesis. However, the role of SETD2 in the development and function of immune cells receives relatively limited attention. In this review, we seek to summarize current knowledge of the biological function and underlying mechanisms of SETD2 and highlight its important role in immune cell biology. By influencing the biological processes of immune cells, SETD2 participates in the pathogenesis of immune-related diseases, including infection, cancers, autoimmune diseases, and inflammatory diseases. Finally, we discuss challenges and prospects for targeting SETD2 in immune cells to provide guidance for treating those diseases in clinical practice.http://www.sciencedirect.com/science/article/pii/S2352304225001114Chromatin biological processesEpidrug discoveryH3K36me3Immune cellsSETD2 |
| spellingShingle | Longmin Chen Yuan Zou Yan Dong Tian Hong Qianqian Xu Jing Zhang Emerging role of SETD2 in the development and function of immune cells Genes and Diseases Chromatin biological processes Epidrug discovery H3K36me3 Immune cells SETD2 |
| title | Emerging role of SETD2 in the development and function of immune cells |
| title_full | Emerging role of SETD2 in the development and function of immune cells |
| title_fullStr | Emerging role of SETD2 in the development and function of immune cells |
| title_full_unstemmed | Emerging role of SETD2 in the development and function of immune cells |
| title_short | Emerging role of SETD2 in the development and function of immune cells |
| title_sort | emerging role of setd2 in the development and function of immune cells |
| topic | Chromatin biological processes Epidrug discovery H3K36me3 Immune cells SETD2 |
| url | http://www.sciencedirect.com/science/article/pii/S2352304225001114 |
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