ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo

ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo

Abstract Neurodegenerative diseases are increasingly prevalent in the aging population, yet no disease‐modifying treatments are currently available. Increasing the expression of the cold‐shock protein RBM3 through therapeutic hypothermia is remarkably neuroprotective. However, systemic cooling poses...

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Main Authors: Marco Preußner, Heather L Smith, Daniel Hughes, Min Zhang, Ann‐Kathrin Emmerichs, Silvia Scalzitti, Diego Peretti, Dean Swinden, Alexander Neumann, Tom Haltenhof, Giovanna R Mallucci, Florian Heyd
Format: Article
Language:English
Published: Springer Nature 2023-03-01
Series:EMBO Molecular Medicine
Subjects:
alternative splicing coupled to nonsense‐mediated decay
hypothermia
neurodegenerative diseases
neuroprotection
RBM3
Online Access:https://doi.org/10.15252/emmm.202217157
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https://doi.org/10.15252/emmm.202217157

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