Effects of two different variants in the MAGT1 gene on B cell subsets, platelet function, and cell glycome composition

Effects of two different variants in the MAGT1 gene on B cell subsets, platelet function, and cell glycome composition

IntroductionX-linked immunodeficiency with magnesium defect, Epstein-Barr virus (EBV) infection and neoplasia (XMEN) disease is caused by hemizygous loss of function (LOF) gene variants in MAGT1. MAGT1 is a plasma membrane transporter of magnesium (Mg2+) that plays a relevant role in immune response...

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Main Authors: Lucía del Pino Molina, Elena Monzón Manzano, Carla Gianelli, Luz Yadira Bravo Gallego, Javier Bujalance Fernández, Paula Acuña, Yolanda Soto Serrano, Keren Reche Yebra, María Bravo García-Morato, Elena Sánchez Zapardiel, Elena G. Arias-Salgado, Rebeca Rodríguez Pena, Nora Butta, Eduardo López Granados
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
XMEN
MAGT1
platelets
calcium influx
B cell phenotype
glycosylation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1547808/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1547808/full

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