Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

Effects from aging in single cells are heterogenous, whereas at the organ- and tissue-levels aging phenotypes tend to appear as stereotypical changes. The mammary epithelium is a bilayer of two major phenotypically and functionally distinct cell lineages: luminal epithelial and myoepithelial cells....

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Bibliographic Details
Main Authors: Rosalyn W Sayaman, Masaru Miyano, Eric G Carlson, Parijat Senapati, Arrianna Zirbes, Sundus F Shalabi, Michael E Todhunter, Victoria E Seewaldt, Susan L Neuhausen, Martha R Stampfer, Dustin E Schones, Mark A LaBarge
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
aging
breast cancer
cancer susceptibility
gene expression variance
lineage fidelity
lumininal epithelia
Online Access:https://elifesciences.org/articles/95720
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https://elifesciences.org/articles/95720

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