Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases
As aberrant Notch signaling has been linked to cancerous growth, Notch inhibitors represent a novel category of targeted oncological therapy. Notch pathways in tumor cells may contribute to proliferation or limit apoptosis and differentiation. Healthy skin differentiation and homeostasis are reliant...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/8842242 |
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| _version_ | 1832547168070664192 |
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| author | Claire J. Wiggins Susan Y. Chon |
| author_facet | Claire J. Wiggins Susan Y. Chon |
| author_sort | Claire J. Wiggins |
| collection | DOAJ |
| description | As aberrant Notch signaling has been linked to cancerous growth, Notch inhibitors represent a novel category of targeted oncological therapy. Notch pathways in tumor cells may contribute to proliferation or limit apoptosis and differentiation. Healthy skin differentiation and homeostasis are reliant on normal Notch expression, and disruption of this signaling has been implicated in dermatological conditions such as hidradenitis suppurativa, psoriasis, atopic dermatitis, and lichen planus. Here, we describe two cases of patients with cutaneous side effects from Notch inhibitor treatment for adenoid cyst carcinoma (ACC) and review the role of Notch signaling in skin disease. By illuminating connections between medication side effects and disease pathogenesis, our goal is to increase awareness of the cutaneous side effects of Notch inhibitor treatment. |
| format | Article |
| id | doaj-art-a22d504471e74226b374f0754e0557e2 |
| institution | Kabale University |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-a22d504471e74226b374f0754e0557e22025-02-03T06:45:49ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712020-01-01202010.1155/2020/88422428842242Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two CasesClaire J. Wiggins0Susan Y. Chon1MD Anderson Cancer Center, Department of Dermatology, 1515 Holcombe Blvd, Houston, TX 77030, USAMD Anderson Cancer Center, Department of Dermatology, 1515 Holcombe Blvd, Houston, TX 77030, USAAs aberrant Notch signaling has been linked to cancerous growth, Notch inhibitors represent a novel category of targeted oncological therapy. Notch pathways in tumor cells may contribute to proliferation or limit apoptosis and differentiation. Healthy skin differentiation and homeostasis are reliant on normal Notch expression, and disruption of this signaling has been implicated in dermatological conditions such as hidradenitis suppurativa, psoriasis, atopic dermatitis, and lichen planus. Here, we describe two cases of patients with cutaneous side effects from Notch inhibitor treatment for adenoid cyst carcinoma (ACC) and review the role of Notch signaling in skin disease. By illuminating connections between medication side effects and disease pathogenesis, our goal is to increase awareness of the cutaneous side effects of Notch inhibitor treatment.http://dx.doi.org/10.1155/2020/8842242 |
| spellingShingle | Claire J. Wiggins Susan Y. Chon Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases Case Reports in Dermatological Medicine |
| title | Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases |
| title_full | Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases |
| title_fullStr | Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases |
| title_full_unstemmed | Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases |
| title_short | Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases |
| title_sort | cutaneous effects of notch inhibitor therapy a report of two cases |
| url | http://dx.doi.org/10.1155/2020/8842242 |
| work_keys_str_mv | AT clairejwiggins cutaneouseffectsofnotchinhibitortherapyareportoftwocases AT susanychon cutaneouseffectsofnotchinhibitortherapyareportoftwocases |