DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controls

DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controls

Abstract Background Epigenetic changes, particularly DNA methylation, are crucial to breast cancer development. Tumor-adjacent normal (AN) tissue frequently serves as a reference for characterizing genomic alterations but is reported to share some characteristics with tumors. However, it is unclear...

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Bibliographic Details
Main Authors: Saya R. Dennis, Takahiro Tsukioki, Gannon Cottone, Wanding Zhou, Patricia A. Ganz, Mary E. Sehl, Yuan Luo, Seema A. Khan, Susan Clare
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Breast Cancer Research
Subjects:
DNA methylation
Breast cancer
Tumor-adjacent normal tissue
Epigenetic profiling
Illumina methylation EPIC BeadChip
Differential methylation analysis
Online Access:https://doi.org/10.1186/s13058-025-02057-y
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https://doi.org/10.1186/s13058-025-02057-y

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