Synthesis, in vitro evaluation and computational modelling of benzene sulfonamide derivatives as Dickkopf 1 inhibitors for anticancer drug development

Synthesis, in vitro evaluation and computational modelling of benzene sulfonamide derivatives as Dickkopf 1 inhibitors for anticancer drug development

Abstract In the modern age of drug discovery sulfanilamide derivatives are known to have great anti-cancerous potential, the current study aimed to synthesize these derivatives in order to evaluate their biological properties against carbonic anhydrase II (CA-II) and Dickkopf − 1(Dkk1) protein which...

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Main Authors: Muhammad Sajjad Bilal, Syeda Abida Ejaz, Sadia Naseem, Pervaiz Ali Channar, Aamer Saeed, Seema Zargar, Rabail Ujan, Reshma Sahito, Qamar Abbas, Tanveer A. Wani
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Sulfanilamide derivatives
Dickkopf-1 protein
Carbonic anhydrase II
Molecular Docking
Density functional theory
Online Access:https://doi.org/10.1038/s41598-025-06890-1
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https://doi.org/10.1038/s41598-025-06890-1

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