Targeting DNA damage repair mechanism by using RAD50-silencing siRNA nanoparticles to enhance radiotherapy in triple negative breast cancer

Targeting DNA damage repair mechanism by using RAD50-silencing siRNA nanoparticles to enhance radiotherapy in triple negative breast cancer

Radiotherapy (RT) is one of major therapeutic modalities in combating breast cancer. In RT, ionizing radiation is employed to induce DNA double-strand breaks (DSBs) as a primary mechanism that causes cancer cell death. However, the induced DNA damage can also trigger the activation of DNA repair mec...

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Bibliographic Details
Main Authors: Abdulmottaleb E. Zetrini, Azhar Z. Abbasi, Chunsheng He, HoYin Lip, Ibrahim Alradwan, Andrew M. Rauth, Jeffrey T. Henderson, Xiao Yu Wu
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Materials Today Bio
Subjects:
DNA damage
RAD50-siRNA-NPs
Radiotherapy
RAD50 downregulation
Triple negative breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424002679
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http://www.sciencedirect.com/science/article/pii/S2590006424002679

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