Neurobiological correlates of schizophrenia-specific and highly pleiotropic genetic risk scores for neuropsychiatric disorders

Neurobiological correlates of schizophrenia-specific and highly pleiotropic genetic risk scores for neuropsychiatric disorders

Abstract Neuropsychiatric disorders show shared and distinct neurobiological correlates. A cross-disorder genome-wide association study (GWAS) identified 23 highly pleiotropic single-nucleotide polymorphisms (SNPs) that were associated with at least four neuropsychiatric disorders, and 22 SNPs that...

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Main Authors: Lydia M. Federmann, Lisa Sindermann, Sabrina Primus, Federico Raimondo, Konrad Oexle, Janik Goltermann, Juliane Winkelmann, Markus M. Nöthen, Katrin Amunts, Thomas W. Mühleisen, Sven Cichon, Simon B. Eickhoff, Felix Hoffstaedter, Udo Dannlowski, Kaustubh R. Patil, Andreas J. Forstner
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03440-1
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https://doi.org/10.1038/s41398-025-03440-1

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