Novel kinetic and developmental transcriptomic pan-stress responses by embryonic stem cells

Novel kinetic and developmental transcriptomic pan-stress responses by embryonic stem cells

Abstract Embryo development is highly susceptible to environmental stressors, contributing significantly to early miscarriages in 70% of human embryos (Cross et al. in Science 266:1508–1518, 1994, Macklon et al. in Hum Reprod Update 8:333–343, 2002). Yet the underlying mechanisms remain poorly under...

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Bibliographic Details
Main Authors: Aditi Singh, Ximena Lu Ruden, Wen Tang, Awoniyi Olumide Awonuga, Douglas Mark Ruden, Steven James Korzeniewski, Elizabeth Ella Puscheck, Hao Feng, Daniel Allen Rappolee
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Embryonic stem cells/ESC
Naive and Formative Pluripotency
Primitive endoderm/extra-embryonic endoderm/XEN
Trophoblast stem cells/TSC
High throughput screening/HTS
Transcriptomics
Online Access:https://doi.org/10.1038/s41598-025-06628-z
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https://doi.org/10.1038/s41598-025-06628-z

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