Effects of the dual orexin receptor antagonist DORA‐22 on sleep in 5XFAD mice

Effects of the dual orexin receptor antagonist DORA‐22 on sleep in 5XFAD mice

Abstract Introduction Sleep disruption is a characteristic of Alzheimer's disease (AD) that may exacerbate disease progression. This study tested whether a dual orexin receptor antagonist (DORA) would enhance sleep and attenuate neuropathology, neuroinflammation, and cognitive deficits in an AD...

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Main Authors: Marilyn J. Duncan, Hannah Farlow, Chairtra Tirumalaraju, Do‐Hyun Yun, Chanung Wang, James A. Howard, Madison N. Sanden, Bruce F. O'Hara, Kristen J. McQuerry, Adam D. Bachstetter
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Sleep‐wake cycles
Sleep fragmentation
Orexin
Dual orexin receptor antagonist
Amyloid β
Neuroinflammation
Online Access:https://doi.org/10.1016/j.trci.2019.01.003
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https://doi.org/10.1016/j.trci.2019.01.003

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