Simultaneous profiling of classic and 11-oxygenated androgens via a novel derivatization method coupled with HPLC-MS/MS: A game-changer for endocrine disorders

Simultaneous profiling of classic and 11-oxygenated androgens via a novel derivatization method coupled with HPLC-MS/MS: A game-changer for endocrine disorders

The accumulation of classic or 11-oxygenated androgens is a hallmark of polycystic ovary syndrome (PCOS). Traditional electrochemiluminescence immunoassays (ECLIA) are limited in their ability to measure a broad spectrum of androgens and may suffer from potential cross-reactivity, leading to inaccur...

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Bibliographic Details
Main Authors: Xianhua Zhang, Huiyu Xu, Yue Sun, Xin Xiong, Lingling Liu, Li Yang, Libo Zhao, Xiaona Li, Rong Li, Rongsheng Zhao
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Talanta Open
Subjects:
QAO
HPLC-MS/MS
MSPE
In-situ derivatization
Classical androgens
11-oxygenated androgens
Online Access:http://www.sciencedirect.com/science/article/pii/S266683192500061X
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http://www.sciencedirect.com/science/article/pii/S266683192500061X

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