Exercise improves depressive-like behavior in adolescent mice by regulating sphingosine and ceramide metabolism through microglial CerS1

Abstract Given the unique onset period of adolescent depression, it is crucial to prioritize treatment modalities that are not only effective but also carry low side effects and promote overall health, with exercise emerging as a notable option. High-intensity interval training (HIIT) and moderate-i...

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Bibliographic Details
Main Authors: Naigang Li, Yuan Yao, Jingyi Du, Dong Wu, Xinghui Qiao, Fan Peng, Fei Meng, Yanan Zhang, Liyan Wang, Aijun Hao, Wenjuan Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08347-7
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