Unidirectional Crosstalk Between NTRK1 and IGF2 Drives ER Stress in Chronic Pain

Unidirectional Crosstalk Between NTRK1 and IGF2 Drives ER Stress in Chronic Pain

<b>Background</b>: Chronic postsurgical pain (CPSP) poses a major clinical challenge due to unresolved links between neurotrophic pathways and endoplasmic reticulum (ER) stress. While Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) modulates ER stress in neuropathic pain, its intera...

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Bibliographic Details
Main Authors: Caixia Zhang, Kaiwen Zhang, Wencui Zhang, Bo Jiao, Xueqin Cao, Shangchen Yu, Mi Zhang, Xianwei Zhang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomedicines
Subjects:
Neurotrophic Tyrosine Kinase Receptor Type 1
Insulin-Like Growth Factor II
Endoplasmic reticulum stress
Chronic Post-surgical Pain
Online Access:https://www.mdpi.com/2227-9059/13/7/1632
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