Low‐Frequency Cyclic Stretch Upregulates the Expression of Nuclear Factor Erythroid 2‐Related Factor 2 in Human Nucleus Pulposus Cells to Inhibit the Resistin‐Induced Interleukin‐20 Expression

Low‐Frequency Cyclic Stretch Upregulates the Expression of Nuclear Factor Erythroid 2‐Related Factor 2 in Human Nucleus Pulposus Cells to Inhibit the Resistin‐Induced Interleukin‐20 Expression

ABSTRACT Background Resistin may connect obesity and intervertebral disc (IVD) degeneration (IDD) and is linked with chronic inflammation. Furthermore, human IDD is characterized by high expression of interleukin‐20 (IL‐20). The response of human nucleus pulposus (NP) cells to tensile forces depends...

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Main Authors: Chia‐Kung Yen, Hung‐Yu Pan, Hsin‐I Chang, Ying‐Chen Lu, Yeau‐Ren Jeng, Cheng‐Nan Chen, Kuo‐Yuan Huang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:JOR Spine
Subjects:
cyclic stretch
IL‐20
intervertebral disc degeneration
Nrf2
nucleus pulposus cells
resistin
Online Access:https://doi.org/10.1002/jsp2.70040
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https://doi.org/10.1002/jsp2.70040

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