GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice

GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice

IntroductionGM-CSF is a pro-inflammatory cytokine that promotes an inflammatory phenotype in myeloid cells. The extent and pattern of GM-CSF expression in immune cells have not been fully elucidated. Our goal was to advance this topic using novel GM-CSF reporter/fate reporter transgenic mice.Methods...

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Bibliographic Details
Main Authors: Gholamreza Azizi, Javad Rasouli, Hamed Naziri, Michael V. Gonzalez, James Garifallou, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad Rostami
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
GM-CSF
CD4+ T cells
CXCR6
fate reporting
neuroinflammation
experimental autoimmune encephalomyelitis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617074/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617074/full

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