Advanced human FcRn knock-in mice for pharmacokinetic profiling of therapeutic antibodies

Advanced human FcRn knock-in mice for pharmacokinetic profiling of therapeutic antibodies

Abstract IgG-based therapeutic antibodies are increasingly adopted for diverse human diseases, such as cancer and autoimmune disorders displaying remarkable therapeutic performance. A key factor in their success lies in the extended half-life of IgG molecules, which is regulated by the pH-dependent...

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Bibliographic Details
Main Authors: SuBin Lee, Munsu Kyung, Miyeon Park, Sunha Park, JaeHoon Lee, Suyeon Kim, Seunghyeon Lee, Migyeong Jo, Sang Taek Jung, Han-Woong Lee
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
FcRn
Pharmacokinetics
Therapeutic IgG
Antibody recycling
Online Access:https://doi.org/10.1038/s41598-025-11168-7
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https://doi.org/10.1038/s41598-025-11168-7

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