Changes in Serum Cytokine Levels in Active Tuberculosis With Treatment
It has been reported that IFN-γ, TNF-α, and IL-12 stimulate, and that IL-10, TGF-β, and IL-4 suppress the protective immune response against tuberculosis. We aim to evaluate changes in the serum levels of pro and antiinflammatory cytokines in active pulmonary tuberculosis (APTB) and the possible eff...
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI.2005.256 |
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| author | Figen Deveci H. Handan Akbulut Teyfik Turgut M. Hamdi Muz |
| author_facet | Figen Deveci H. Handan Akbulut Teyfik Turgut M. Hamdi Muz |
| author_sort | Figen Deveci |
| collection | DOAJ |
| description | It has been reported that IFN-γ, TNF-α, and IL-12
stimulate, and that IL-10, TGF-β, and IL-4 suppress the
protective immune response against tuberculosis. We aim
to evaluate changes in the serum levels of pro and
antiinflammatory cytokines in active pulmonary tuberculosis
(APTB) and the possible effects of treatment on these changes.
Serum IL-12p40, IL-4, IL-10, TNF-α, IFN-γ, and
TGF-β1 levels were determined in 20 APTB cases (group 1)
before and 2, 4, and 6 months after therapy. The same parameters
were also determined in 9 inactive pulmonary tuberculosis (IPTB)
cases (group 2) and 9 healthy controls (HC, group 3). Before
treatment, the mean serum IFN-γ, TNF-α, and IL-10
levels in group 1 were statistically higher than those in group 2
(P=.001, P=.024, P=.016, resp) or group 3 (P=.003, P=.002, P=.011, resp). The levels in group 1 decreased
significantly after treatment (P=.001 for IFN-γ,
P=.004
for TNF-α, P=.000 for IL-10). The serum levels
of IL-12p40 were significantly higher in group 1 than in group 3
(P=.012) and decreased insignificantly after treatment. There
was no difference in serum IL-4 and TGF-β1 levels among the
groups (P>.05). Because the serum IL-12p40, IL-10, TNF-α,
and IFN-γ levels were high in APTB, we believe that these
cytokines have important roles in the immune response to
Mycobacterium tuberculosis (M tuberculosis).
These parameters could be used in follow-up as indicators of the
success of APTB therapy. |
| format | Article |
| id | doaj-art-a0e5f3d2eff0476682dd3dec72f8dac6 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a0e5f3d2eff0476682dd3dec72f8dac62025-02-03T05:52:32ZengWileyMediators of Inflammation0962-93511466-18612005-01-012005525626210.1155/MI.2005.256Changes in Serum Cytokine Levels in Active Tuberculosis With TreatmentFigen Deveci0H. Handan Akbulut1Teyfik Turgut2M. Hamdi Muz3Department of Chest Diseases, Firat Medical Center, Faculty of Medicine, Firat University, Elazig 23119, TurkeyDepartment of Immunology, Faculty of Medicine, Firat University, Elazig 23119, TurkeyDepartment of Chest Diseases, Firat Medical Center, Faculty of Medicine, Firat University, Elazig 23119, TurkeyDepartment of Chest Diseases, Firat Medical Center, Faculty of Medicine, Firat University, Elazig 23119, TurkeyIt has been reported that IFN-γ, TNF-α, and IL-12 stimulate, and that IL-10, TGF-β, and IL-4 suppress the protective immune response against tuberculosis. We aim to evaluate changes in the serum levels of pro and antiinflammatory cytokines in active pulmonary tuberculosis (APTB) and the possible effects of treatment on these changes. Serum IL-12p40, IL-4, IL-10, TNF-α, IFN-γ, and TGF-β1 levels were determined in 20 APTB cases (group 1) before and 2, 4, and 6 months after therapy. The same parameters were also determined in 9 inactive pulmonary tuberculosis (IPTB) cases (group 2) and 9 healthy controls (HC, group 3). Before treatment, the mean serum IFN-γ, TNF-α, and IL-10 levels in group 1 were statistically higher than those in group 2 (P=.001, P=.024, P=.016, resp) or group 3 (P=.003, P=.002, P=.011, resp). The levels in group 1 decreased significantly after treatment (P=.001 for IFN-γ, P=.004 for TNF-α, P=.000 for IL-10). The serum levels of IL-12p40 were significantly higher in group 1 than in group 3 (P=.012) and decreased insignificantly after treatment. There was no difference in serum IL-4 and TGF-β1 levels among the groups (P>.05). Because the serum IL-12p40, IL-10, TNF-α, and IFN-γ levels were high in APTB, we believe that these cytokines have important roles in the immune response to Mycobacterium tuberculosis (M tuberculosis). These parameters could be used in follow-up as indicators of the success of APTB therapy.http://dx.doi.org/10.1155/MI.2005.256 |
| spellingShingle | Figen Deveci H. Handan Akbulut Teyfik Turgut M. Hamdi Muz Changes in Serum Cytokine Levels in Active Tuberculosis With Treatment Mediators of Inflammation |
| title | Changes in Serum Cytokine Levels in Active Tuberculosis With Treatment |
| title_full | Changes in Serum Cytokine Levels in Active Tuberculosis With Treatment |
| title_fullStr | Changes in Serum Cytokine Levels in Active Tuberculosis With Treatment |
| title_full_unstemmed | Changes in Serum Cytokine Levels in Active Tuberculosis With Treatment |
| title_short | Changes in Serum Cytokine Levels in Active Tuberculosis With Treatment |
| title_sort | changes in serum cytokine levels in active tuberculosis with treatment |
| url | http://dx.doi.org/10.1155/MI.2005.256 |
| work_keys_str_mv | AT figendeveci changesinserumcytokinelevelsinactivetuberculosiswithtreatment AT hhandanakbulut changesinserumcytokinelevelsinactivetuberculosiswithtreatment AT teyfikturgut changesinserumcytokinelevelsinactivetuberculosiswithtreatment AT mhamdimuz changesinserumcytokinelevelsinactivetuberculosiswithtreatment |