What is known and unknown about the role of neuroendocrine genes Ptprn and Ptprn2
The protein tyrosine phosphatase receptors N and N2 are encoded by the Ptprn and Ptprn2 genes expressed in neuroendocrine cells of the hypothalamus, pituitary gland, and diffuse neuroendocrine system, including the pancreas, lung, and intestine. Unlike other members of the protein tyrosine phosphata...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1531723/full |
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| author | Stanko S. Stojilkovic Srdjan J. Sokanovic Stephanie Constantin |
| author_facet | Stanko S. Stojilkovic Srdjan J. Sokanovic Stephanie Constantin |
| author_sort | Stanko S. Stojilkovic |
| collection | DOAJ |
| description | The protein tyrosine phosphatase receptors N and N2 are encoded by the Ptprn and Ptprn2 genes expressed in neuroendocrine cells of the hypothalamus, pituitary gland, and diffuse neuroendocrine system, including the pancreas, lung, and intestine. Unlike other members of the protein tyrosine phosphatase receptor family, PTPRN and PTPRN2 lack protein tyrosine phosphatase activity due to mutation of two residues in their intracellular catalytic domains. However, during evolution these proteins acquired new cellular roles beyond tyrosine dephosphorylation in the centralized and diffuse neuroendocrine systems. Here we discuss the current understanding and lack of information about the actions of these proteins, focusing on neuroendocrine cells of the hypothalamus, pituitary, and pancreas. |
| format | Article |
| id | doaj-art-a0e091e64832407e83e7ad8be2b1e1e0 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-a0e091e64832407e83e7ad8be2b1e1e02025-01-24T07:13:42ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011610.3389/fendo.2025.15317231531723What is known and unknown about the role of neuroendocrine genes Ptprn and Ptprn2Stanko S. StojilkovicSrdjan J. SokanovicStephanie ConstantinThe protein tyrosine phosphatase receptors N and N2 are encoded by the Ptprn and Ptprn2 genes expressed in neuroendocrine cells of the hypothalamus, pituitary gland, and diffuse neuroendocrine system, including the pancreas, lung, and intestine. Unlike other members of the protein tyrosine phosphatase receptor family, PTPRN and PTPRN2 lack protein tyrosine phosphatase activity due to mutation of two residues in their intracellular catalytic domains. However, during evolution these proteins acquired new cellular roles beyond tyrosine dephosphorylation in the centralized and diffuse neuroendocrine systems. Here we discuss the current understanding and lack of information about the actions of these proteins, focusing on neuroendocrine cells of the hypothalamus, pituitary, and pancreas.https://www.frontiersin.org/articles/10.3389/fendo.2025.1531723/fullPTPRNPTPRN2GnRH neuronskisspeptinergic neuronspancreatic β-cellsgonadotrophs |
| spellingShingle | Stanko S. Stojilkovic Srdjan J. Sokanovic Stephanie Constantin What is known and unknown about the role of neuroendocrine genes Ptprn and Ptprn2 Frontiers in Endocrinology PTPRN PTPRN2 GnRH neurons kisspeptinergic neurons pancreatic β-cells gonadotrophs |
| title | What is known and unknown about the role of neuroendocrine genes Ptprn and Ptprn2 |
| title_full | What is known and unknown about the role of neuroendocrine genes Ptprn and Ptprn2 |
| title_fullStr | What is known and unknown about the role of neuroendocrine genes Ptprn and Ptprn2 |
| title_full_unstemmed | What is known and unknown about the role of neuroendocrine genes Ptprn and Ptprn2 |
| title_short | What is known and unknown about the role of neuroendocrine genes Ptprn and Ptprn2 |
| title_sort | what is known and unknown about the role of neuroendocrine genes ptprn and ptprn2 |
| topic | PTPRN PTPRN2 GnRH neurons kisspeptinergic neurons pancreatic β-cells gonadotrophs |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1531723/full |
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