In Silico Prediction of Tetrastatin-Derived Peptide Interactions with αvβ3 and α5β1 Integrins

In Silico Prediction of Tetrastatin-Derived Peptide Interactions with αvβ3 and α5β1 Integrins

<b>Background/Objectives</b>: Tetrastatin, the globular non collagenous (NC1) domain of the α4 chain of collagen IV, was previously demonstrated to inhibit melanoma progression. We identified the minimal active sequence (QKISRCQVCVKYS: QS-13) that reproduced the anti-tumor effects of who...

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Bibliographic Details
Main Authors: Vivien Paturel, Stéphanie Baud, Christophe Schneider, Sylvie Brassart-Pasco
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
collagen
integrins
MD simulations
molecular docking
tetrastatin
Online Access:https://www.mdpi.com/1424-8247/18/7/940
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