Telpegfilgrastim for chemotherapy-induced neutropenia in patients with non-small cell lung cancer: a multicentre, randomized, phase 3 study

Telpegfilgrastim for chemotherapy-induced neutropenia in patients with non-small cell lung cancer: a multicentre, randomized, phase 3 study

Abstract Background Chemotherapy-induced neutropenia (CIN) is usually managed by recombinant human granulocyte colony stimulating factor (rhG-CSF) and pegylated rhG-CSF (PEG-rhG-CSF). This study evaluated the efficacy and safety of telpegfilgrastim, a novel Y-shaped PEG-rhG-CSF, for CIN prophylaxis...

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Main Authors: Yuankai Shi, Xinshuai Wang, Zhidong Pei, Huaqiu Shi, Yanjun Zhang, Tienan Yi, Jiazhuan Mei, Yanzhen Guo, Youhong Dong, Tianjiang Ma, Qingyuan Zhang, Xiaojing Jia, Zhengqiu Zhu, Shen Xu, Yanyan Liu, Hongrui Niu, Weimei Jiang, Xiaodong Jiang, Shengyu Zhou, Li Sun
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Cancer
Subjects:
Recombinant human granulocyte colony stimulating factor
Pegylated recombinant human granulocyte colony stimulating factor
Telpegfilgrastim
Neutropenia
Non-small-cell lung cancer
Online Access:https://doi.org/10.1186/s12885-025-13736-6
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https://doi.org/10.1186/s12885-025-13736-6

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