The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis

The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis

Abstract Systemic immune changes have been implicated in amyotrophic lateral sclerosis (ALS), but precise mechanisms and cellular targets remain unknown. Neuromuscular junction (NMJ) denervation is another major pathophysiological event in ALS, but it remains unclear whether immune system dysregulat...

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Main Authors: Bernát Nógrádi, Kinga Molnár, Rebeka Kristóf, Orsolya Horváth, Yu-Ting Huang, Zara Ridgway, Amaia Elicegui, Sandra Fuertes-Alvarez, Sonia Alonso-Martin, Gábor J. Szebeni, Nikolett Gémes, Abdullah Ramadan, Hannah L. Smith, István A. Krizbai, Roland Patai, László Siklós, Péter Klivényi, Helena Chaytow, Thomas H. Gillingwater
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62351-3
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https://doi.org/10.1038/s41467-025-62351-3

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