Inflammatory mediators and the RAGE pathway in placental tissues of pregnancies complicated by severe preeclampsia

Inflammatory mediators and the RAGE pathway in placental tissues of pregnancies complicated by severe preeclampsia

IntroductionPreeclampsia (PE) is a complex multisystem disorder of pregnancy associated with abnormal placentation, vascular anomalies, and systemic inflammation and hypertension. Previous research assessing inflammatory triggers of the condition used plasma, amniotic fluid, or explant samples. Stud...

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Main Authors: Neelima Chandra, Thomas D. Kimble, Kathleen R. Heim, Sharon M. Anderson, Andrew P. Wong, Andrea R. Thurman, Gustavo F. Doncel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Reproductive Health
Subjects:
calcium binding protein (S-100)
cyclooxygenase 2 (COX-2)
high mobility group box protein (HMGB1)
interleukin 8 (IL-8)
nuclear factor kappa B p65 sub unit (NF-kBp65)
receptors of advanced glycation end products (RAGE)
Online Access:https://www.frontiersin.org/articles/10.3389/frph.2025.1587699/full
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https://www.frontiersin.org/articles/10.3389/frph.2025.1587699/full

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